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Juerg Feldmann

Fortiori Design LLC
Posts: 1,530
In performance  and or  activity the single  goal is  to " survive" So  we look for energy who allows us to do that. The answer is  simple O2 is what we look for.
 n the past due to limitation of technology we  used indirect methods  with all thee benefits we had   at the time but as well the limitations we where aware of. So  when energy supply O2 is getting  hard to come by we will have a regulation over the central  systems  to  make a priority list  on where  can I afford  to  limit O2  supply  and where not.
 The first place you  will be able to recue  O2  supply is in the periphery  and there in structures   which use  O2  but may  be not needed  so  extreme to survive.
 Example  the arms muscles  in a  runner or cyclist  or  ice hockey player  and so on.
 This is  one of the reason we  adjust a MOXY  to a non-involved muscle.
 Once we see a  clear change in tHb  and SmO2  there  than we  have a great indication, that more vital delivery  systems need   O2  and can't afford  to sent it  to the working muscles.  After that we may see a  sharp drop in SmO2  in the main muscles,. There are some limitations to that we can discuss later.
 In short : The idea, that  performance may be limited  over  brain actions  seems to  get more and more support.
 Here a really nice study  who would   push us towards this  idea as well.


Central and peripheral fatigue: interaction during cycling exercise in humans.

Department of Medicine, University of Utah, Salt Lake City, UT, USA.
Medicine and science in sports and exercise(Impact Factor: 4.48). 04/2011; 43(11):2039-45. DOI: 10.1249/MSS.0b013e31821f59ab
Source: PubMed

ABSTRACT Existing evidence suggests that exercise-induced alterations of the metabolic milieu of locomotor muscle and associated peripheral muscle fatigue affect the central projection of thin-fiber muscle afferents. These neurons provide inhibitory feedback to the CNS and thereby influence the magnitude of central motor drive during high-intensity whole-body endurance exercise. The purpose of this proposed feedback loop would be to regulate and restrict the development of exercise-induced peripheral muscle fatigue and/or associated sensory feedback to an "individual critical threshold." This centrally mediated restriction in the development of peripheral locomotor muscle fatigue might thereby help to prevent excessive disturbance of muscle homeostasis and potential harm to the organism. It seems that the regulatory mechanism is dominant during exercise under "normal" conditions but might become secondary in the face of extreme environmental influences such as severe hypoxia or heat. Most recent data are used to emphasize how the proposed feedback loop might be a key factor limiting performance during high-intensity whole-body endurance exercise.

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