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Development Team Member
Posts: 14
I thought the Moxy forum would appreciate this paper.

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Michael J. Joyner Darren P. Casey

Juerg Feldmann

Fortiori Design LLC
Posts: 1,530
Thanks  for this  great input. It is  nice to see, that  many of our   sometimes  strange or  crazy looking ideas  can be backed  up  by accepted  groups. So  this is  why  we strongly believe  NIRS is  what it is  and  should not be degraded  to an old  great  but outdated  idea  of   any threshold  or points. Thanks again for this  great  feedback.
Juerg Feldmann

Fortiori Design LLC
Posts: 1,530
Here a  short  section of the abstract

Michael J. Joyner and Darren P. Casey

Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; and Department of Physical Therapy and

Rehabilitation Science, University of Iowa, Iowa City, Iowa

L Joyner MJ, Casey DP. Regulation of Increased Blood Flow (Hyperemia) to Muscles

During Exercise: A Hierarchy of Competing Physiological Needs. Physiol Rev 95: 549– 601, 2015; doi:10.1152/physrev.00035.2013.—This review focuses on how blood flow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in the atmosphere with the

contracting muscles where it is consumed. In this context, we take a top down approach and review the basics of oxygen consumption at rest and during exercise in humans, how these values change with training, and the systemic hemodynamic adaptations that support them. We highlight the very high muscle blood flow responses to exercise discovered in the 1980s. We also discuss the vasodilating factors in the contracting muscles responsible for these very high flows. Finally, the competition between demand for blood flow by contracting muscles and maximum systemic cardiac output is discussed as a potential challenge to blood pressure regulation during heavy large muscle mass or whole body exercise in humans. At this time, no one dominant dilator mechanism accounts for exercise hyperemia. Additionally, complex interactions between the sympathetic nervous system and the microcirculation facilitate high levels of systemic oxygen extraction and permit just enough sympathetic control of blood flow to contracting muscles to regulate blood pressure during large muscle mass exercise in humans.

And here  how  it looks  when this happens   with MOXY 5/1/5  ( shown  long  back on this forum  in different sections.

D rest strat thb smo2 symm.jpg 
above  a  situation of the 1 mn rest  at tehe start
of a 5/1/5
 No problme  wiht BP  and CO  can easy minait  teghincrease in   blood folow  .

Thna as  more    capillarisation increases    the  situation chnages  at rest  as the sudden stop of muscle contraction does not help to support the BP  and as a reflex reaction we see  with a smal delay a  vasoconstriction to avoid  a  dangereous drop in  BP. see below at the end  of a  5/1/5  test same person same test  done in Santa Monica  during a RED Bull MOXY seminar.

D rest end thb smo2.jpg  

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