Here a short section of the abstract
Michael J. Joyner and Darren P. Casey
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; and Department of Physical Therapy and
Rehabilitation Science, University of Iowa, Iowa City, Iowa
L Joyner MJ, Casey DP. Regulation of Increased Blood Flow (Hyperemia) to Muscles
During Exercise: A Hierarchy of Competing Physiological Needs. Physiol Rev 95: 549â€“ 601, 2015; doi:10.1152/physrev.00035.2013.â€”This review focuses on how blood ï¬‚ow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood ï¬‚ow to the contracting muscles links oxygen in the atmosphere with the
contracting muscles where it is consumed. In this context, we take a top down approach and review the basics of oxygen consumption at rest and during exercise in humans, how these values change with training, and the systemic hemodynamic adaptations that support them. We highlight the very high muscle blood ï¬‚ow responses to exercise discovered in the 1980s. We also discuss the vasodilating factors in the contracting muscles responsible for these very high ï¬‚ows. Finally, the competition between demand for blood ï¬‚ow by contracting muscles and maximum systemic cardiac output is discussed as a potential challenge to blood pressure regulation during heavy large muscle mass or whole body exercise in humans. At this time, no one dominant dilator mechanism accounts for exercise hyperemia. Additionally, complex interactions between the sympathetic nervous system and the microcirculation facilitate high levels of systemic oxygen extraction and permit just enough sympathetic control of blood ï¬‚ow to contracting muscles to regulate blood pressure during large muscle mass exercise in humans.
And here how it looks when this happens with MOXY 5/1/5 ( shown long back on this forum in different sections.
above a situation of the 1 mn rest at tehe start of a 5/1/5
No problme wiht BP and CO can easy minait teghincrease in blood folow .
Thna as more capillarisation increases the situation chnages at rest as the sudden stop of muscle contraction does not help to support the BP and as a reflex reaction we see with a smal delay a vasoconstriction to avoid a dangereous drop in BP. see below at the end of a 5/1/5 test same person same test done in Santa Monica during a RED Bull MOXY seminar.