Here a replay I am behind with for teh people looking for metrics and math.
I am wondering if there is a similar way of looking at the Moxy data to calculate a cost, in O2/Hb terms for work done.
I was thinking maybe venous blood flow or total Hb O2 extraction during the interval...
But wondered if anyone had a concrete measure (and formula) we could use.
There are different options and here some common once . The leading research used ideas are nicely showed in the Artinis handouts.
Here ideas on quantifying tHb
3.10. Quantitation of absolute blood flow
The principle of measuring organ blood flow with NIRS is based on the Fick
principle which states that the accumulation of a tracer in an organ equals the
difference between the inflow (arterial concentration x flow) and outflow (venous
concentration x flow). If we measure within the transit time of the tracer through
the organ the venous concentration will be zero. In NIRS the tracer used is a bolus
of O2Hb, which can be induced by suddenly increasing the inspired oxygen
concentration. The concentration of the bolus can be measured by attaching a
pulse oximetry probe onto the organ. The increase of O2Hb as measured by NIRS
represents the accumulation of the bolus into the organ. The blood flow (BF, in
mlâ—100g-1 â—min-1) through the organ is then given by the change of O2Hb divided
by the product of the arterial hemoglobin concentration (cHb, in gâ—ml-1) times the
integral of change in arterial saturation (SaO2, in %) : K is constant representing the molecular weight of hemoglobin, the tissue density and a metric conversion factor. This methodology has first been described by Edwards et al.  for the determination of cerebral blood flow in newborn
and afterwards by others who made a comparison with the 133Xe clearance method [Skov et al. 1991, Bucher et al. 1993], finding an acceptable correlation between the two methods in newborn. Elwell et al. [1992, 1993] have used it to determine the cerebral blood flow in adults.
Some of the disadvantages of the methodology are firstly that a certain degree of
hypoxia with subsequent hyperoxia is needed to induce the O2Hb bolus. If this
intervention is inert is not known. Furthermore an adequate lung function is
necessary. Secondly a reliable beat-to-beat pulse oximeter is needed for the
measurements, which is generally a problem. Later studies have shown that this
technique is not very reliable.