How does MOXY relates to lactate.
I try to make it very simple here.
Lactate and SmO2 have one thing in common, both give us feedback that energy is used. An increase in SmO2 can indicate an influx of O2 which is more than what is used at that particular load. Problem:
This can be a good sign, as I move more O2 in than I actually need for the moment and I use optimal O2 for ATP production. But it as well can mean I actually load great SmO2 but I would in fact need more O2 for ATP production and despite the fact , that it is there it is not bio -available.
Lactate as well is an indication , that I use energy and one part of the energy I used is crate O2 independent.
Same here. I can have an increase in lactate but really have no problem with that , as I am perfectly balance the H + situation. So lactate is helping as one part of the buffering situation.. So I may go perfectly O2 dependent but had somewhere returned to use glycogen and stimulated a a very high glycogen release and one reaction was lactate production despite a lot of O2 availablity.
( Lactate paradox.
R. G. Shulman*† and D. L. Rothman‡
Departments of *Molecular Biophysics and Biochemistry and ‡Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510
Contributed by R. G. Shulman, November 21, 2000Stimulated by recent 13C and 31P NMR studies of exercising muscle, we propose a model of the energetics of contraction
"O2 is used in the oxidative phosphorylation. )This mechanism utilizes the rapid conversion of glycogen phosphorylase, the ‘‘fight-or-flight’’ enzyme, to its active form. Lactate is necessarily generated by this pathway to serve as a time buffer between fast and slow energy needs, which resolves the paradoxical generation of lactate in well oxygenated tissue.
Now when we look in practical terms on MOXY and lactate , than one part which may be most overlooked but where MOXY clearly can replace the invasive nature of lactate is in the MAX LASS testing.
If , there is a use for lactate to find a steady state , than it is the MAX LASS steady state testing , which is complex and long to do but impressive as somebody will poke you takes blood has gloves on and looks very smart when doing it. and it is painfull so it has to be good ( smile )
I made a lot of money this way.
Max lass steady state is most liley the itensity where we have a stable SmO2 on a low level of SmO2 testing.
To backed this up there are studies done on this in europe (Italy)
Determination of maximal lactate steady state in healthy adults: can NIRS help?
Bellotti C, Calabria E, Capelli C, Pogliaghi S.
Department of Neurological, Neuropsychological, Morphological and Exercise Sciences, School of Exercise and Sport Sciences, University of Verona, Italy.
We tested the hypothesis that the maximal lactate steady state (MLSS) can be accurately determined in healthy subjects based on measures of deoxygenated hemoglobin (deoxyHb), an index of oxygen extraction measured noninvasively by near-infrared spectroscopy (NIRS).
Thirty-two healthy men (mean ± SD age = 48 ± 17 yr, range = 23-74 yr) performed an incremental cycling test to exhaustion and square wave tests for MLSS determination. Cardiorespiratory variables were measured bbb and deoxyHb was monitored noninvasively on the right vastus lateralis with a quantitative NIRS device. The individual values of V˙O2 and HR corresponding to the MLSS were calculated and compared to the NIRS-derived MLSS (NIRSMLSS) that was, in turn, determined by double linear function fitting of deoxyHb during the incremental exercise.
V˙O2 and HR at MLSS were 2.25 ± 0.54 L·min (76% ± 9% V˙O2max) and 133 ± 14 bpm (81% ± 7% HRmax), respectively. Muscle O2 extraction increased as a function of exercise intensity up to a deflection point, NIRSMLSS, at which V˙O2 and HR were 2.23 ± 0.59 L·min (76% ± 9% V˙O2max) and 136 ± 17 bpm (82% ± 8% HRmax), respectively. For both V˙O2 and HR, the difference of NIRSMLSS from MLSS values was not significant and the measures were highly correlated (r = 0.81 and r = 0.76). The Bland-Altman analysis confirmed a nonsignificant bias for V˙O2 and HR (-0.015 L·min and 3 bpm, respectively) and a small imprecision of 0.26 L·min and 8 bpm.
A plateau in muscle O2 extraction was demonstrated in coincidence with MLSS during an incremental cycling exercise, confirming the hypothesis that this functional parameter can be accurately estimated with a quantitative NIRS device. The main advantages of NIRSMLSS over lactate-based techniques are the noninvasiveness and the time/cost efficiency.